Publications AsiDNA

Abstract – Journal of Clinical Oncology

Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy Article de référence sur les nouvelles approches dans le domaine du DDR, dont AsiDNA™, et leur intérêt dans des traitements en association Lien vers l’article en anglais : https://ascopubs.org/doi/10.1200/JCO.18.02050

Posters – AACR 2019

Liens vers les posters en anglais: Molecular analysis of the mechanism of action of AsiDNA™ brings new clues on DNA damage response regulation AsiDNA™, a novel DNA repair inhibitor to radio-sensitize aggressive medulloblastoma subtypes AsiDNA™ abrogates acquired resistance to PARP inhibitors Development of a Biomarker-driven patient selection strategy for AsiDNA™ treatment

Posters – AACR 2018

Lien vers les articles en anglais: AsiDNATM and HDAC inhibitors: A cross-potentiation team work to kill tumor cells Evolution of tumor cells under Dbait (AsiDNA) treatment results in “autosensitization”

Poster – AACR 2017

Lien vers l’article en anglais: AsiDNATM induces tumor sensitivity to PARP inhibitors in homologous recombination proficient breast cancer

Résultats de l’étude de phase 1 DRIIM – British Journal of Cancer, 2016 (anglais)

2016 DRIIM study: First-in-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma   Abstract Background: DT01 is a DNA-repair inhibitor preventing recruitment of DNA-repair enzymes at damage sites. Safety, pharmacokinetics and preliminary efficacy through intratumoural and peritumoural injections of DT01 were evaluated in combination with radiotherapy in a first-in-human…read more →

Poster – ASCO 2015

Lien vers l’article en anglais: First-in-human phase I study of the DNA repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma

Poster – AACR 2013

Lien vers l’article en anglais: Preclinical study of Dbait, an inhibitor of three DNA repair pathways, in breast cancer treatment